Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804310 | 0.89 | PDE1B (0.45) | PDE1BMAPK1METAP2WNT3ARAB9A | |
| SCHEMBL16804276 | 0.89 | HDAC6 (0.46) | PDE1BMAPK1HDAC6 | |
| SCHEMBL16804451 | 0.85 | GLO1 (0.41) | GLO1METAP2GRM2ALDH1A1GAA | |
| SCHEMBL16804456 | 0.83 | STAT6 (0.46) | MAPK1GLO1HDAC6KMT2A | |
| SCHEMBL16804228 | 0.77 | METAP2 (0.42) | METAP2RAB9AHDAC6GAA | |
| SCHEMBL16794772 | 0.75 | DGAT1 (0.38) | METAP2MEN1KMT2A | |
| SCHEMBL18852703 | 0.75 | HDAC6 (0.43) | METAP2HDAC6 | |
| SCHEMBL18852711 | 0.75 | METAP2 (0.41) | METAP2MAPTRAB9AHDAC6ALDH1A1 | |
| SCHEMBL16804205 | 0.74 | HDAC6 (0.45) | METAP2HDAC6 | |
| SCHEMBL16804404 | 0.74 | METAP2 (0.44) | METAP2MAPTRAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015087151-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-06-18 | — | — | WO | disclosed |