SCHEMBL16807164

SCHEMBL16807164

CCc1cc(CO)ccc1-c1ccc(CCc2ccc(C)cc2)cc1CC

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.43
IGF1R P08069 1/20 0.41
ALOX15 P16050 1/20 0.41
BACE1 P56817 2/20 0.40
VDR P11473 2/20 0.40
GPR84 Q9NQS5 1/20 0.39
NR3C2 P08235 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP2A6 P11509 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
FFAR4 Q5NUL3 4/20 0.36
FFAR1 O14842 3/20 0.36
SLC5A2 P31639 2/20 0.36
SLC5A1 P13866 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16807160 0.90 CYP4F2 (0.42) DAOIGF1RALOX15BACE1VDR
SCHEMBL16807163 0.90 BACE1 (0.42) DAOBACE1VDRGPR84ALDH1A1
SCHEMBL16807175 0.88 CNR1 (0.46) BACE1VDRGPR84
SCHEMBL16807159 0.87 IGF1R (0.46) DAOIGF1RALOX15BACE1VDR
SCHEMBL15725315 0.86 BACE1 (0.41) BACE1ALDH1A1MAPTFFAR4FFAR1
SCHEMBL16807161 0.86 IGF1R (0.49) DAOIGF1RALOX15BACE1GPR84
SCHEMBL16807177 0.85 ALDH1A1 (0.45) GPR84ALDH1A1
SCHEMBL16807087 0.85 BACE1 (0.41) BACE1ALDH1A1MAPTFFAR4FFAR1
SCHEMBL16807162 0.84 IGF1R (0.47) IGF1RALOX15
SCHEMBL16807182 0.84 RARB (0.47) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150166890-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2015-06-18 US disclosed
US-20150166890-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2015-06-18 US disclosed