Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.66 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | DRD4 | P21917 | 3/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835871 | 0.94 | HTR1B (0.64) | HTR1BDRD2DRD4DRD3CACNA1B | |
| Hydrochloric Acid SCHEMBL21595945 | 0.92 | HTR1B (0.62) | HTR1BDRD2DRD4DRD3CACNA1B | |
| SCHEMBL14174988 | 0.82 | DRD2 (0.71) | HTR1BDRD2DRD4DRD3HTR1D | |
| SCHEMBL6255082 | 0.82 | HTR1B (0.68) | HTR1BDRD2DRD4DRD3HTR1D | |
| SCHEMBL23067925 | 0.81 | DRD4 (0.76) | DRD2DRD4DRD3TSHR | |
| SCHEMBL10338308 | 0.80 | MEN1 (0.60) | DRD2DRD4DRD3L3MBTL1TSHR | |
| SCHEMBL6849549 | 0.80 | HTR1B (0.66) | HTR1BDRD2DRD4DRD3HTR1D | |
| SCHEMBL19022034 | 0.80 | DRD2 (0.59) | DRD2DRD4DRD3CACNA1BL3MBTL1 | |
| SCHEMBL12939856 | 0.80 | HTR1B (0.66) | HTR1BDRD2DRD4DRD3CACNA1B | |
| SCHEMBL19860387 | 0.80 | DRD2 (0.59) | DRD2DRD4DRD3CACNA1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106312-A1 | METHODS OF MODULATING LEVELS OF IL-6 AND PD-L1 | DREXEL UNIVERSITY (US) | 2017-06-22 | — | — | WO | disclosed |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2016-12-15 | — | — | US | disclosed |
| US-9388126-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | DREXEL UNIVERSITY | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | HTR1B 454/4885DRD2 1233/4885DRD4 1625/4885 |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | HTR1B 491/4885DRD2 1343/4885DRD4 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.