Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16793805 | 0.90 | TBK1 (0.60) | TBK1RIPK1BTKCSF1RKIT | |
| SCHEMBL25592986 | 0.89 | TBK1 (0.56) | TBK1RIPK1BTKCSF1RKIT | |
| SCHEMBL16793789 | 0.87 | TBK1 (0.55) | TBK1RIPK1BTKCSF1RKIT | |
| SCHEMBL16793853 | 0.87 | BTK (0.57) | TBK1RIPK1BTKKIT | |
| SCHEMBL4067498 | 0.82 | RIPK1 (0.59) | TBK1RIPK1BTKCSF1R | |
| SCHEMBL28129363 | 0.79 | TBK1 (0.68) | TBK1RIPK1BTK | |
| SCHEMBL4062847 | 0.79 | RIPK1 (0.58) | TBK1RIPK1BTKCSF1R | |
| SCHEMBL23775255 | 0.78 | ALDH1A1 (0.58) | — | |
| SCHEMBL17290038 | 0.75 | TBK1 (1.00) | TBK1 | |
| SCHEMBL18197638 | 0.74 | TBK1 (0.48) | TBK1RIPK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089327-A1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN IDEC MA INC. (US) | 2015-06-18 | — | — | WO | disclosed |