Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TPH1 | P17752 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 6/20 | 0.32 |
| ▸ | HTR2B | P41595 | 6/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16814948 | 0.82 | NCF1 (0.50) | NCF1TPH1BRD4PNMTMC4R | |
| SCHEMBL27834649 | 0.78 | NCF1 (0.71) | NCF1PNMTMC4RDPP4HTR2C | |
| SCHEMBL28294095 | 0.78 | NCF1 (0.56) | NCF1BRD4PNMTMC4RDPP4 | |
| SCHEMBL16814961 | 0.77 | TPH1 (0.37) | NCF1TPH1BRD4MC4RHTR2C | |
| SCHEMBL30607725 | 0.76 | NCF1 (0.51) | NCF1BRD4MC4R | |
| SCHEMBL16814882 | 0.75 | NCF1 (0.77) | NCF1PNMTMC4RDPP4 | |
| SCHEMBL111729 | 0.75 | NCF1 (0.72) | NCF1PNMTMC4R | |
| SCHEMBL16814951 | 0.73 | NCF1 (0.70) | NCF1 | |
| SCHEMBL110730 | 0.73 | NCF1 (0.70) | NCF1 | |
| SCHEMBL28753504 | 0.73 | NCF1 (0.55) | NCF1BRD4PNMTMC4RHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |