Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.57 |
| ▸ | LGMN | Q99538 | 2/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | TPH1 | P17752 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834649 | 0.86 | NCF1 (0.71) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL16814882 | 0.82 | NCF1 (0.77) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL111729 | 0.82 | NCF1 (0.72) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL110730 | 0.81 | NCF1 (0.70) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL16814951 | 0.81 | NCF1 (0.70) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL27585360 | 0.79 | NCF1 (0.58) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL28294095 | 0.78 | NCF1 (0.56) | NCF1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL111193 | 0.78 | NCF1 (0.57) | NCF1LGMNCYP2A13ALDH1A1RAB9A | |
| SCHEMBL110927 | 0.78 | NCF1 (0.87) | NCF1KDM4EHTR1A | |
| SCHEMBL29505669 | 0.78 | NCF1 (0.87) | NCF1KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |