SCHEMBL16818451

SCHEMBL16818451

CC(C)(C)[Si](OCc1cc(Cl)cc(COS(C)(=O)=O)c1)(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 8/20 0.33
MCTS1 Q9ULC4 5/20 0.33
SLC16A1 P53985 5/20 0.33
TACR1 P25103 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
ACLY P53396 2/20 0.31
AR P10275 1/20 0.30
PKM P14618 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16818502 0.86 ACLY (0.32) SLC16A3MCTS1TACR1CA1CA2
SCHEMBL5672961 0.82 SLC16A3 (0.33) SLC16A3MCTS1SLC16A1
SCHEMBL16818604 0.82 TACR1 (0.34) SLC16A3MCTS1SLC16A1TACR1PKM
SCHEMBL17803752 0.77 ACLY (0.34) SLC16A3MCTS1SLC16A1ACLY
SCHEMBL19197241 0.74 SMYD2 (0.38) CA1CA2CA9CYP1A2CYP3A4
SCHEMBL31124766 0.74 TSHR (0.35) SLC16A3TACR1CYP3A4
SCHEMBL31124717 0.74 TRPA1 (0.35) TACR1CYP3A4
SCHEMBL1314001 0.73 AGXT (0.42) CYP3A4CYP2D6
SCHEMBL4426073 0.73 IDO1 (0.48) TACR1CA1CA2CA9
SCHEMBL22750792 0.72 KDM4E (0.40) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2021-08-17 US disclosed
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2021-08-17 US disclosed
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2019-10-15 US disclosed
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2019-10-15 US disclosed
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2018-01-04 US disclosed
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2018-01-04 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2016-06-16 US disclosed
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2016-06-16 US disclosed
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2016-06-16 US disclosed
US-9309246-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2016-04-12 US disclosed
US-9309246-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2016-04-12 US disclosed
US-9309246-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2016-04-12 US disclosed
WO-2015095492-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2015-06-25 WO disclosed
WO-2015095492-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2015-06-25 WO disclosed
US-20150175604-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2015-06-25 US disclosed
US-20150175604-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2015-06-25 US disclosed
US-20150175604-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2015-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS BRD1, BRD3, BRD2 SLC16A3 4299/4885MCTS1 1515/4885SLC16A1 4291/4885
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors BRD1, BRD3, BRD2 SLC16A3 4299/4885MCTS1 1515/4885SLC16A1 4291/4885
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS BRD1, BRD3, BRD2 SLC16A3 4299/4885MCTS1 1515/4885SLC16A1 4291/4885
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors BRD1, BRD3, BRD2 SLC16A3 4299/4885MCTS1 1515/4885SLC16A1 4291/4885
US-20150175604-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS BRD1, BRD3, BRD2 SLC16A3 4299/4885MCTS1 1515/4885SLC16A1 4291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.