Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23112200 | 0.88 | SCN9A (0.61) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL7425171 | 0.88 | RAB9A (0.63) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL20630423 | 0.87 | SCN9A (0.51) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL30151772 | 0.86 | SCN9A (0.59) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL2062662 | 0.86 | SCN9A (0.59) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL13744590 | 0.85 | MEN1 (0.51) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL7994019 | 0.84 | SCN9A (0.48) | SCN9ACA12CA1CA2CA9 | |
| SCHEMBL7995494 | 0.82 | SCN9A (0.48) | SCN9AKMT2ACA12CA1CA2 | |
| SCHEMBL2061299 | 0.82 | SCN9A (0.55) | SCN9ARAB9AKMT2ACA12CA1 | |
| SCHEMBL15869790 | 0.81 | ALDH1A1 (0.55) | SCN9ARAB9AKMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |