Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | GFER | P55789 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | YWHAG | P61981 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824943 | 0.85 | NR1H2 (0.49) | MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16166942 | 0.83 | AKR1C3 (0.49) | MAPTALDH1A1GAAGFERHSD17B10 | |
| SCHEMBL22450644 | 0.82 | MAPT (0.56) | MAPTALDH1A1GAAGFERHSD17B10 | |
| SCHEMBL27737005 | 0.81 | GAA (0.46) | ALDH1A1GAAMEN1KMT2ALMNA | |
| SCHEMBL28094402 | 0.80 | ALDH1A1 (0.49) | MAPTALDH1A1GFERMEN1KMT2A | |
| SCHEMBL16824932 | 0.80 | SETDB1 (0.41) | MAPTALDH1A1GAAGFERHSD17B10 | |
| SCHEMBL792373 | 0.79 | NPSR1 (0.43) | MAPTALDH1A1GAAGFERHSD17B10 | |
| SCHEMBL1812623 | 0.78 | MAPT (0.46) | MAPTALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL14320645 | 0.78 | MAPT (0.56) | MAPTALDH1A1GAAGFERHSD17B10 | |
| SCHEMBL16853272 | 0.78 | HTR3E (0.46) | MAPTALDH1A1GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083625-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | Almac Discovery Limited (GB) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092431-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |