Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | LMNA | P02545 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824835 | 0.83 | MAPT (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL16824939 | 0.83 | MAPT (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL1814622 | 0.74 | ALDH1A1 (0.65) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL30310805 | 0.74 | ALDH1A1 (0.65) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL16570120 | 0.73 | LMNA (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL17958742 | 0.73 | LMNA (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL1813408 | 0.73 | MAPT (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL18186426 | 0.71 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL16824823 | 0.71 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL1971542 | 0.71 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083625-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | Almac Discovery Limited (GB) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092431-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |