Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073484 | 0.84 | KDM4E (0.47) | KDM4ESMN1; SMN2TSHRALDH1A1GAA | |
| SCHEMBL5656421 | 0.79 | NPC1 (0.43) | KDM4ESMN1; SMN2TSHRALDH1A1GAA | |
| SCHEMBL3952611 | 0.79 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2ALOX15ALDH1A1GAA | |
| SCHEMBL6245335 | 0.78 | TDP1 (0.50) | KDM4ESMN1; SMN2ALOX15TSHRALDH1A1 | |
| SCHEMBL27792560 | 0.76 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1GAAHTT | |
| SCHEMBL3158948 | 0.76 | TDP1 (0.51) | KDM4ESMN1; SMN2ALOX15TSHRALDH1A1 | |
| SCHEMBL4558224 | 0.71 | KMT2A (0.48) | SMN1; SMN2ALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL9022868 | 0.71 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2ALOX15TSHRALDH1A1 | |
| SCHEMBL8261149 | 0.71 | SMN1; SMN2 (0.71) | KDM4ESMN1; SMN2TSHRALDH1A1HTT | |
| SCHEMBL4439280 | 0.71 | SLC6A4 (0.53) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083584-A1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS | Sunshine Lake Pharma Co., Ltd. (CN) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015090232-A1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-06-25 | — | — | WO | disclosed |