Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSH | P09668 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245335 | 0.85 | TDP1 (0.50) | KMT2AMEN1ATMMAPTTDP1 | |
| SCHEMBL3158948 | 0.82 | TDP1 (0.51) | KMT2AMEN1ATMMAPTTDP1 | |
| SCHEMBL4475826 | 0.78 | CTSV (0.39) | KMT2AMEN1ATMMAPTUSP2 | |
| Pyridine SCHEMBL28255435 | 0.74 | ADRB1 (0.44) | CYP2D6HTR1A | |
| SCHEMBL11548078 | 0.73 | CA12 (0.52) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL29995599 | 0.73 | CA12 (0.52) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL29593166 | 0.73 | KMT2A (0.43) | KMT2AMEN1ATMMAPTTDP1 | |
| SCHEMBL11073491 | 0.73 | NCEH1 (0.44) | KMT2AMEN1MAPTTDP1LMNA | |
| SCHEMBL16825239 | 0.71 | KDM4E (0.43) | KMT2AMEN1ALDH1A1ALOX15LMNA | |
| SCHEMBL11092326 | 0.70 | HRH3 (0.51) | KMT2AMEN1MAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569342-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| EP-1667972-B1 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD (GB) | 2013-06-19 | — | — | EP | disclosed |
| US-7504419-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER SINGH | 2009-03-17 | — | — | US | disclosed |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. | 2008-11-20 | — | — | US | disclosed |
| EP-1667972-A2 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD. (GB) | 2006-06-14 | — | — | EP | disclosed |
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER S (GB) | 2005-09-15 | — | — | US | disclosed |
| WO-2005023767-A2 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD. (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | KMT2A 1239/4885MEN1 4392/4885ATM 4810/4885 |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | KMT2A 1239/4885MEN1 4392/4885ATM 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.