Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28601116 | 0.78 | HTT (0.45) | ALDH1A1HIF1AHTTCYP2C19CYP1A2 | |
| SCHEMBL4412 | 0.77 | — | — | |
| SCHEMBL5611325 | 0.77 | HCAR2 (0.44) | ALDH1A1HIF1AKMT2ACYP2C19TP53 | |
| SCHEMBL8085681 | 0.77 | HCAR2 (0.44) | ALDH1A1HIF1AKMT2ACYP2C19TP53 | |
| SCHEMBL5611334 | 0.77 | HCAR2 (0.44) | ALDH1A1HIF1AKMT2ACYP2C19TP53 | |
| SCHEMBL28285089 | 0.76 | — | — | |
| SCHEMBL697706 | 0.75 | ALDH1A1 (0.35) | ALDH1A1HIF1AKMT2ACYP2C19TP53 | |
| Alcohol SCHEMBL28357108 | 0.74 | HCAR2 (0.43) | ALDH1A1CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL294874 | 0.74 | — | — | |
| SCHEMBL28082232 | 0.74 | MIF (0.35) | ALDH1A1HIF1AKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212181-A2 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | Seagen Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| EP-3082878-B1 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | SEAGEN INC (US) | 2022-10-05 | — | — | EP | disclosed |
| US-20220054650-A1 | Methylene Carbamate Linkers for use with Targeted-Drug Conjugates | SEATTLE GENETICS, INC. | 2022-02-24 | — | — | US | disclosed |
| US-11116847-B2 | Methylene carbamate linkers for use with targeted-drug conjugates | SEAGEN INC. (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3082878-A1 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | Seattle Genetics, Inc. (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160303254-A1 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | SEAGEN INC. | 2016-10-20 | — | — | US | disclosed |
| CN-105813653-A | Methylene carbamate linkers for use with target-drug conjugates | 西雅图基因公司 | 2016-07-27 | — | — | CN | disclosed |
| WO-2015095755-A1 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | SEATTLE GENETICS, INC. (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11116847-B2 | Methylene carbamate linkers for use with targeted-drug conjugates | MCL1, BID, MTDH | ALDH1A1 1928/4885HIF1A 2494/4885KMT2A 1132/4885 |
| US-20160303254-A1 | METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES | LIG1, LIG4, LIG3 | ALDH1A1 1740/4885HIF1A 2550/4885KMT2A 918/4885 |
| US-20220054650-A1 | Methylene Carbamate Linkers for use with Targeted-Drug Conjugates | MCL1, BID, MTDH | ALDH1A1 1928/4885HIF1A 2494/4885KMT2A 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.