Sugi Predict

Sugi Predict / Compounds / SCHEMBL16828359

SCHEMBL16828359

SCHEMBL16828359

CC=CC[C](C)C(C)CCCC

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 4/20 0.38
▸ FDPS P14324 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.32
▸ ACHE P22303 1/20 0.32
▸ BACE1 P56817 1/20 0.32
▸ CA2 P00918 4/20 0.31
▸ TSHR P16473 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ DNM1 Q05193 1/20 0.31
▸ FFAR4 Q5NUL3 1/20 0.31
▸ ACE2 Q9BYF1 1/20 0.31
▸ TRPA1 O75762 1/20 0.31
▸ DDAH1 O94760 1/20 0.31
▸ GAPDH P04406 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ FFAR1 O14842 1/20 0.31
▸ MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9764078 0.77 CA1 (0.43) CA1FDPSALDH1A1CA2DNM1
SCHEMBL7116034 0.77 CA1 (0.43) CA1FDPSALDH1A1CA2DNM1
SCHEMBL9242261 0.75 CA1 (0.41) CA1FDPSALDH1A1ACHEBACE1
SCHEMBL9242259 0.75 CA1 (0.41) CA1FDPSALDH1A1ACHEBACE1
SCHEMBL4642212 0.74 CA1 (0.44) CA1FDPSALDH1A1CA2DNM1
SCHEMBL9547068 0.72 — —
SCHEMBL3678904 0.71 CA1 (0.40) CA1FDPSFFAR4ACE2TRPA1
SCHEMBL547239 0.71 CA1 (0.44) CA1FDPSALDH1A1TSHRFFAR4
SCHEMBL101976 0.71 — —
SCHEMBL17182195 0.70 CA1 (0.52) CA1FDPSFFAR4ACE2TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226313-A1 CEACAM5 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF SEAGEN INC. 2024-07-11 — — US disclosed
US-12029736-B2 Camptothecin derivatives and conjugates thereof MEDIBOSTON LIMITED (HK) 2024-07-09 — — US disclosed
CN-111558049-B Methylene carbamate linkers for use with target-drug conjugates 西雅图基因公司 2024-06-21 — — CN disclosed
CN-111569086-B Methylene carbamate linkers for use with target-drug conjugates 西雅图基因公司 2024-06-21 — — CN disclosed
WO-2024108053-A1 CEACAM5 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF SANOFI (FR) 2024-05-23 — — WO disclosed
US-20240108744-A1 AURISTATIN DERIVATIVES AND CONJUGATES THEREOF FORTVITA BIOLOGICS LIMITED (CN) 2024-04-04 — — US disclosed
WO-2024023735-A1 AURISTATIN DERIVATIVES AND CONJUGATES THEREOF MEDIBOSTON LIMITED (CN) 2024-02-01 — — WO disclosed
CN-117377652-A Cyclopropane analogues of N- (trans-4-hydroxycyclohexyl) -6-phenylhexanamide and related compounds 线粒体情感状态公司 2024-01-09 — — CN disclosed
US-20230381321-A1 CAMPTOTHECIN CONJUGATES SEAGEN INC. 2023-11-30 — — US disclosed
WO-2023178289-A2 CAMPTOTHECIN CONJUGATES SEAGEN INC. (US) 2023-09-21 — — WO disclosed
US-11116847-B2 Methylene carbamate linkers for use with targeted-drug conjugates SEAGEN INC. (US) 2021-09-14 — — US disclosed
WO-2021067861-A1 CAMPTOTHECIN PEPTIDE CONJUGATES SEAGEN INC. (US) 2021-04-08 — — WO disclosed
EP-3773736-A1 CAMPTOTHECIN PEPTIDE CONJUGATES Seagen Inc. (US) 2021-02-17 — — EP disclosed
CN-111558049-A Methylene carbamate linkers for use with target-drug conjugates 西雅图基因公司 2020-08-21 — — CN disclosed
CN-105813653-B Methylene carbamate linkers for use with target-drug conjugates 西雅图基因公司 2020-06-26 — — CN disclosed
US-20190343828-A1 CAMPTOTHECIN PEPTIDE CONJUGATES SEATTLE GENETICS, INC. (US) 2019-11-14 — — US disclosed
WO-2019195665-A1 CAMPTOTHECIN PEPTIDE CONJUGATES SEATTLE GENETICS, INC. (US) 2019-10-10 — — WO disclosed
EP-3082878-A1 METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES Seattle Genetics, Inc. (US) 2016-10-26 — — EP disclosed
US-20160303254-A1 METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES SEAGEN INC. 2016-10-20 — — US disclosed
WO-2015095755-A1 METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES SEATTLE GENETICS, INC. (US) 2015-06-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240226313-A1 CEACAM5 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF EPCAM, TOP2A, SPAG5 CA1 57/4885FDPS 4322/4885ALDH1A1 388/4885
US-11116847-B2 Methylene carbamate linkers for use with targeted-drug conjugates MCL1, BID, MTDH CA1 256/4885FDPS 1627/4885ALDH1A1 1928/4885
US-12029736-B2 Camptothecin derivatives and conjugates thereof TOP2A, TOP1, XPA CA1 1954/4885FDPS 800/4885ALDH1A1 1163/4885
US-20230381321-A1 CAMPTOTHECIN CONJUGATES DCLRE1A, TOP2A, PAICS CA1 1113/4885FDPS 3521/4885ALDH1A1 1069/4885
US-20240108744-A1 AURISTATIN DERIVATIVES AND CONJUGATES THEREOF AURKA, AURKC, AURKB CA1 1415/4885FDPS 2613/4885ALDH1A1 628/4885
US-20160303254-A1 METHYLENE CARBAMATE LINKERS FOR USE WITH TARGETED-DRUG CONJUGATES LIG1, LIG4, LIG3 CA1 811/4885FDPS 1967/4885ALDH1A1 1740/4885
US-20190343828-A1 CAMPTOTHECIN PEPTIDE CONJUGATES VIP, DCLRE1A, UACA CA1 1146/4885FDPS 1987/4885ALDH1A1 2863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback