Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | UBE2N | P61088 | 4/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164750 | 0.82 | HTR7 (0.43) | NPC1RAB9AKMT2AACKR3MAPT | |
| SCHEMBL15754826 | 0.80 | NPC1 (0.60) | L3MBTL1KDM4ENPC1LMNARAB9A | |
| SCHEMBL28291686 | 0.77 | KMT2A (0.50) | L3MBTL1KDM4ENPC1LMNARAB9A | |
| SCHEMBL19778587 | 0.75 | KMT2A (0.54) | L3MBTL1KDM4ENPC1LMNARAB9A | |
| SCHEMBL168402 | 0.75 | KMT2A (0.54) | L3MBTL1KDM4EKMT2AUBE2NMAPT | |
| SCHEMBL14150735 | 0.74 | KMT2A (0.64) | L3MBTL1KDM4EKMT2AUBE2NACKR3 | |
| SCHEMBL11105039 | 0.72 | HDAC3 (0.54) | KDM4ENPC1LMNARAB9AKMT2A | |
| SCHEMBL5962907 | 0.71 | SCN4A (0.49) | L3MBTL1KDM4EKMT2A | |
| SCHEMBL13860920 | 0.71 | GAA (0.54) | L3MBTL1KDM4ENPC1LMNAMAPT | |
| SCHEMBL15412947 | 0.68 | KDM4E (0.44) | L3MBTL1KDM4ENPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |