Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30030622 | 0.83 | KDM4E (0.44) | KMT2ARXRAGRIN1GRIN2BMAPT | |
| SCHEMBL23749443 | 0.83 | KDM4E (0.44) | KMT2ARXRAGRIN1GRIN2BMAPT | |
| SCHEMBL168303 | 0.82 | L3MBTL1 (0.49) | KMT2AACKR3MAPTNPC1RAB9A | |
| SCHEMBL168701 | 0.80 | SCN9A (0.40) | HTR7RXRAGRIN1GRIN2BNR3C2 | |
| SCHEMBL30029894 | 0.77 | F2 (0.36) | HTR7RXRAGRIN1GRIN2BACKR3 | |
| SCHEMBL23749312 | 0.77 | F2 (0.36) | HTR7RXRAGRIN1GRIN2BACKR3 | |
| SCHEMBL15412955 | 0.72 | RXRA (0.43) | KMT2AAURKAABL1LCKMET | |
| SCHEMBL20249708 | 0.70 | CRHR1 (0.40) | HTR7KMT2ARXRAGRIN1GRIN2B | |
| SCHEMBL16201981 | 0.69 | MAPT (0.53) | HTR7RXRAGRIN1GRIN2BMAPT | |
| SCHEMBL164749 | 0.67 | AURKA (0.51) | KMT2AAURKAABL1LCKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |