Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 20/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 20/20 | 0.50 |
| ▸ | DRD3 | P35462 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3770650 | 0.80 | ADRB2 (0.61) | ADRB2ADRB1DRD3 | |
| SCHEMBL4554541 | 0.79 | ADRB2 (0.59) | ADRB2ADRB1DRD3 | |
| SCHEMBL2212359 | 0.74 | ADRB2 (0.55) | ADRB2ADRB1DRD3 | |
| SCHEMBL2212515 | 0.74 | ADRB2 (0.55) | ADRB2ADRB1DRD3 | |
| SCHEMBL2215025 | 0.74 | ADRB2 (0.55) | ADRB2ADRB1DRD3 | |
| SCHEMBL3685866 | 0.74 | ADRB2 (0.48) | ADRB2ADRB1DRD3DRD2ADRA1D | |
| SCHEMBL2208618 | 0.73 | ADRB2 (0.54) | ADRB2ADRB1DRD3 | |
| SCHEMBL1683025 | 0.72 | ADRB2 (0.52) | ADRB2ADRB1DRD3DRD2ADRA1D | |
| SCHEMBL1683044 | 0.69 | ADRB2 (0.45) | ADRB2ADRB1DRD3 | |
| SCHEMBL2209598 | 0.68 | ADRB2 (0.43) | ADRB2ADRB1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303266-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A 4-HYDROXY-2-OXO-2, 3- DIHYDRO-1, 3-BENZOTHIAZOL-7-YL COMPOUND FOR MODULATION OF BETA2-ADRENORECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |