Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242107 | 0.81 | RXRA (0.44) | RXRAGRIN1GRIN2BALDH1A1ROCK2 | |
| SCHEMBL167859 | 0.79 | RXRA (0.43) | RXRAGRIN1GRIN2BALDH1A1ROCK2 | |
| SCHEMBL24685887 | 0.67 | NQO1 (0.48) | TUBB1 | |
| SCHEMBL1620757 | 0.65 | LMNA (0.56) | ALDH1A1TUBB1L3MBTL1PDE4D | |
| SCHEMBL27075044 | 0.64 | RXRA (0.41) | RXRAGRIN1GRIN2BP2RX7MEN1 | |
| SCHEMBL29958206 | 0.64 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2ATUBB1L3MBTL1 | |
| SCHEMBL1121313 | 0.64 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2ATUBB1L3MBTL1 | |
| SCHEMBL31587512 | 0.63 | RXRA (0.43) | RXRAGRIN1GRIN2BALDH1A1HDAC3 | |
| SCHEMBL19211513 | 0.63 | RXRA (0.67) | RXRAGRIN1GRIN2BP2RX7 | |
| SCHEMBL31337221 | 0.63 | LRRK2 (0.47) | RXRAGRIN1GRIN2BALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |