Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384957 | 0.82 | KEAP1 (0.55) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL12376528 | 0.82 | KEAP1 (0.52) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL9524664 | 0.77 | KEAP1 (0.52) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL599138 | 0.76 | HCAR3 (1.00) | HCAR3RAB9AMEN1KMT2AHPGD | |
| SCHEMBL19236877 | 0.74 | KEAP1 (0.49) | HCAR3KEAP1NFE2L2HPGDPOLB | |
| SCHEMBL9524820 | 0.74 | KEAP1 (0.52) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL12369468 | 0.72 | HCAR3 (0.76) | HCAR3RAB9AMEN1KMT2AHPGD | |
| SCHEMBL21624765 | 0.72 | HCAR3 (0.60) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL3938770 | 0.72 | HCAR3 (0.60) | HCAR3KEAP1RAB9AMEN1KMT2A | |
| SCHEMBL2387217 | 0.72 | KEAP1 (0.47) | HCAR3KEAP1RAB9ANFE2L2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083614-A1 | NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092713-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |