Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 10/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20312710 | 0.84 | KEAP1 (0.46) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL9524664 | 0.82 | KEAP1 (0.52) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL12376528 | 0.77 | KEAP1 (0.52) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL8884360 | 0.76 | CYP19A1 (0.60) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL9523659 | 0.75 | CYP19A1 (0.50) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL25044540 | 0.75 | KDM4E (0.40) | KEAP1RAB9AMEN1KMT2AHCAR3 | |
| SCHEMBL16831706 | 0.74 | HCAR3 (0.60) | KEAP1RAB9AMEN1KMT2AHCAR3 | |
| SCHEMBL28687687 | 0.72 | TDO2 (0.58) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL20873827 | 0.72 | TDO2 (0.58) | KEAP1SLC9A1RAB9AMEN1KMT2A | |
| SCHEMBL9525014 | 0.70 | KEAP1 (0.50) | KEAP1SLC9A1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |