Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGAV | P06756 | 2/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16836717 | 0.88 | MTNR1A (0.43) | HTR2CMTNR1AMTNR1BCASRMCL1 | |
| SCHEMBL16836727 | 0.82 | MCL1 (0.40) | HTR2CMTNR1AMTNR1BCASRMCL1 | |
| SCHEMBL18857020 | 0.81 | HTR2C (0.59) | HTR2CMTNR1AMTNR1BHTR2AMAPT | |
| SCHEMBL16836696 | 0.76 | MCL1 (0.42) | MTNR1AMTNR1BMCL1ITGB3ITGAV | |
| SCHEMBL18423138 | 0.74 | MMP1 (0.46) | — | |
| SCHEMBL16836697 | 0.74 | MMP1 (0.46) | — | |
| SCHEMBL16836698 | 0.74 | MMP1 (0.46) | — | |
| SCHEMBL16836688 | 0.73 | MCL1 (0.40) | MTNR1AMTNR1BMCL1MAOAMAOB | |
| SCHEMBL16569329 | 0.72 | CASR (0.38) | CASR | |
| SCHEMBL7960647 | 0.70 | AGXT (0.53) | MAPTSMN1; SMN2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083567-B1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-9624206-B2 | Antibacterial 1H-indazole and 1H-indole derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2017-04-18 | — | — | US | disclosed |
| US-20170029411-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-02-02 | — | — | US | disclosed |
| EP-3083567-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | Actelion Pharmaceuticals Ltd (CH) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015091741-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029411-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | MRPL21, PYM1, DRD3 | HTR2C 73/4885MTNR1A 529/4885MTNR1B 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.