Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18857024 | 0.85 | MTNR1A (0.62) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL4204521 | 0.83 | MTNR1A (0.60) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL3817124 | 0.83 | HTR2C (0.59) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL6803161 | 0.83 | HTR2C (0.63) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL10413240 | 0.82 | MTNR1A (0.59) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL16836744 | 0.81 | HTR2C (0.41) | HTR2CMTNR1AMTNR1BHTR2AMAPT | |
| SCHEMBL7232114 | 0.81 | HTR2C (0.64) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL23956095 | 0.81 | HTR7 (0.67) | HTR2CMTNR1AMTNR1BHTR2AHTR7 | |
| SCHEMBL3332582 | 0.81 | HTR2C (0.81) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL18856948 | 0.81 | MTNR1A (0.58) | HTR2CMTNR1AMTNR1BHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017082924-A1 | PEPTIDE AND PEPTIDE MIMETIC BINDING ANTAGONISTS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2017-05-18 | — | — | WO | disclosed |