Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168061 | 0.87 | SRC (0.38) | ALDH1A1CTSVCTSLSLKSTK10 | |
| SCHEMBL168459 | 0.86 | EGFR (0.49) | — | |
| SCHEMBL249906 | 0.77 | MEN1 (0.46) | ALDH1A1CTSVCTSLHTR1AADRA1D | |
| SCHEMBL248994 | 0.77 | HTR1A (0.40) | ALDH1A1CTSVCTSLHTR1AADRA1D | |
| SCHEMBL168495 | 0.73 | PIN1 (0.50) | ALDH1A1CTSVCTSLHTR1AADRA1D | |
| SCHEMBL6386114 | 0.72 | SRC (0.58) | — | |
| SCHEMBL168060 | 0.71 | EGFR (0.52) | — | |
| SCHEMBL31439366 | 0.69 | KAT2B (0.38) | ALDH1A1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6386277 | 0.69 | SRC (0.66) | — | |
| SCHEMBL7414623 | 0.68 | POLB (0.54) | CTSVCTSLMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| EP-2609082-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |