Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.44 |
| ▸ | MGLL | Q99685 | 5/20 | 0.44 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22220046 | 0.87 | MGLL (0.41) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL16834912 | 0.83 | DRD2 (0.39) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL18100026 | 0.82 | MGLL (0.44) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL17813682 | 0.81 | MGLL (0.36) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL16834889 | 0.81 | PTGS1 (0.47) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL19666091 | 0.80 | MGLL (0.37) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL17813686 | 0.77 | OPRM1 (0.34) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL23889659 | 0.77 | DRD2 (0.49) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL22698762 | 0.77 | MGLL (0.41) | PTGS1PTGS2MGLLFAAHSPHK1 | |
| SCHEMBL19061723 | 0.72 | MGLL (0.44) | PTGS1PTGS2MGLLFAAHOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016205176-A1 | ANTIBODIES AND IMMUNOCONJUGATES | GENENTECH, INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |