Lomustine

Lomustine

SCHEMBL168490

O=NN(CCCl)C(=O)NC1CCCCC1.O=P1(N(CCCl)CCCl)NCCCO1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 2/20 0.64
PDE4A P27815 1/20 0.64
ADRA1A P35348 1/20 0.64
NPSR1 Q6W5P4 1/20 0.57
KDM4E B2RXH2 1/20 0.56
ALOX15 P16050 1/20 0.56
MAPK1 P28482 1/20 0.56
ALDH1A1 P00352 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
MEN1 O00255 1/20 0.36
ABCB11 O95342 1/20 0.36
GSR P00390 1/20 0.36
TSHR P16473 1/20 0.36
HTT P42858 1/20 0.36
BLM P54132 1/20 0.36
PMP22 Q01453 1/20 0.36
KMT2A Q03164 1/20 0.36
CRYZ Q08257 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Semustine SCHEMBL15569770 0.92 ADRA2A (0.65) ADRA2APDE4AADRA1ANPSR1KDM4E
Cyclophosphamide Anhydrous SCHEMBL5364682 0.84 NPSR1 (0.61) ADRA2APDE4AADRA1ANPSR1KDM4E
Lomustine SCHEMBL868328 0.80 ADRA2A (1.00) ADRA2APDE4AADRA1AKDM4EALDH1A1
Lomustine SCHEMBL3995 0.80 ADRA2A (1.00) ADRA2APDE4AADRA1AKDM4EALDH1A1
Lomustine SCHEMBL28262197 0.77 ADRA2A (0.94) ADRA2APDE4AADRA1AKDM4EALDH1A1
Lomustine SCHEMBL28123007 0.76 ADRA2A (0.91) ADRA2APDE4AADRA1AKDM4EALDH1A1
Lomustine SCHEMBL28159683 0.76 ADRA2A (0.91) ADRA2APDE4AADRA1AKDM4EALDH1A1
Cyclophosphamide Anhydrous SCHEMBL14192809 0.76 NPSR1 (1.00) NPSR1KDM4EALOX15MAPK1CRYZ
Cyclophosphamide Anhydrous SCHEMBL20542636 0.76 NPSR1 (1.00) NPSR1KDM4EALOX15MAPK1CRYZ
Cyclophosphamide Anhydrous SCHEMBL1285823 0.76 NPSR1 (1.00) NPSR1KDM4EALOX15MAPK1CRYZ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672951-A1 QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS Merck Patent GmbH (DE) 2020-07-01 EP disclosed
EP-3672952-A1 BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS Merck Patent GmbH (DE) 2020-07-01 EP disclosed
EP-3668516-A1 STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID Merck Patent GmbH (DE) 2020-06-24 EP disclosed
EP-3661941-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS Merck Patent GmbH (DE) 2020-06-10 EP disclosed
WO-2019038214-A1 QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2019-02-28 WO disclosed
WO-2019038215-A1 BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2019-02-28 WO disclosed
WO-2019034673-A1 STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID MERCK PATENT GMBH (DE) 2019-02-21 WO disclosed
WO-2019025099-A1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2019-02-07 WO disclosed
EP-2994471-A1 MACROCYCLES AS KINASE INHIBITORS Merck Patent GmbH (DE) 2016-03-16 EP disclosed
EP-2976328-A1 PIPERAZINE DERIVATIVES AS FASN INHIBITORS Merck Patent GmbH (DE) 2016-01-27 EP disclosed
EP-2352732-A1 2, 5-DIAMINO-SUBSTITUTED PYRIDO Ý4, 3-D¨PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER Merck Patent GmbH (DE) 2011-08-10 EP disclosed
EP-2254889-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF Merck Patent GmbH (DE) 2010-12-01 EP disclosed
WO-2010115491-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2010-10-14 WO disclosed
WO-2010112124-A1 AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2010-10-07 WO disclosed
WO-2010080253-A1 TRICYCLIC AZAINDOLES MERCK PATENT GMBH (DE) 2010-07-15 WO disclosed
WO-2010078897-A1 NOVEL POLYMORPHIC FORMS OF 3-(1-{3-[5-(1-METHYL-PIPERIDIN-4YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF MERCK PATENT GMBH (DE) 2010-07-15 WO disclosed
WO-2010077530-A1 C-RING MODIFIED TRICYCLIC BENZONAPHTHIRIDINONE PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2010-07-08 WO disclosed
WO-2010072295-A1 NOVEL POLYMORPHIC FORMS OF 6-(1-METHYL-1H-PYRAZOL-4-YL)-2-{3-[5-(2-MORPHOLIN-4-YL-ETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-2H-PYRIDAZIN-3-ONE DIHYDROGENPHOSPHATE AND PROCESSES OF MANUFACTURING THEREOF MERCK PATENT GMBH (DE) 2010-07-01 WO disclosed
WO-2010063352-A1 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER MERCK PATENT GMBH (DE) 2010-06-10 WO disclosed
WO-2009108670-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK SERONO S.A. (CH) 2009-09-03 WO disclosed