Lomustine

Lomustine

SCHEMBL3995

O=NN(CCCl)C(=O)NC1CCCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 2/20 1.00
PDE4A P27815 1/20 1.00
ADRA1A P35348 1/20 1.00
ALDH1A1 P00352 4/20 0.75
SMN1; SMN2 Q16637 4/20 0.75
KMT2A Q03164 3/20 0.53
MEN1 O00255 1/20 0.53
ABCB11 O95342 1/20 0.53
GSR P00390 1/20 0.53
TSHR P16473 1/20 0.53
HTT P42858 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
EPHX1 P07099 7/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
EPHX2 P34913 2/20 0.42
MAPT P10636 1/20 0.42
KDM4E B2RXH2 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lomustine SCHEMBL868328 1.00 ADRA2A (1.00) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Lomustine SCHEMBL28262197 0.97 ADRA2A (0.94) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Lomustine SCHEMBL28159683 0.95 ADRA2A (0.91) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Lomustine SCHEMBL28123007 0.95 ADRA2A (0.91) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Lomustine SCHEMBL1831239 0.93 ADRA2A (0.86) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Semustine SCHEMBL2350016 0.91 ALDH1A1 (0.92) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
Lomustine SCHEMBL863570 0.91 ADRA2A (0.83) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
SCHEMBL4634654 0.88 ADRA2A (0.79) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
SCHEMBL3341311 0.87 ADRA2A (0.77) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2
SCHEMBL3341308 0.87 ADRA2A (0.77) ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 136148 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026107377-A1 PHARMACOLOGICAL RE-ACTIVATION OF MUTANT PVHL KARANICOLAS JOHN (US) 2026-05-21 WO claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
US-20260139071-A1 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses JANSSEN BIOTECH INC (US) 2026-05-21 US claimed
US-20260137700-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE SK BIOPHARMACEUTICALS CO LTD (KR) 2026-05-21 US claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
EP-4743490-A1 HUMANIZED ANTI-CD7 ANTIBODY Christian-Albrechts-Universität zu Kiel (DE) 2026-05-20 EP claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
WO-1989007453-A1 MEDICINAL PREPARATIONS CHARACTERIZED BY A COMBINATION OF CYTOSTATIC AGENTS, HORMONAL THERAPEUTIC AGENTS AND PHOSPHONE DERIVATIVES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1989-08-24 WO claimed
WO-1989002734-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-04-06 WO claimed
EP-0273754-A2 Method of enhancing the biodistribution of antibody for localization in lesions CITY OF HOPE NATIONAL MEDICAL CENTER (US) 1988-07-06 EP claimed
EP-0227593-A1 Use of chelating agents THE HOSPITAL FOR SICK CHILDREN (CA) 1987-07-01 EP claimed
US-4631289-A ANTITUMOR AGENTS; CELL SENSITIZATION NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-12-23 US claimed
EP-0095906-B1 IMPROVEMENTS RELATING TO COMPOUNDS USEFUL IN RADIOTHERAPY OR CHEMOTHERAPY NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-10-22 EP claimed
EP-0189849-A2 Method for treatment of neuroectodermal malignancies and epithelial carcinomas in humans Sloan-Kettering Institute For Cancer Research (US) 1986-08-06 EP claimed
EP-0120907-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY Aston Molecules Limited (GB) 1984-10-10 EP claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0095906-A1 Improvements relating to compounds useful in radiotherapy or chemotherapy NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1983-12-07 EP claimed