SCHEMBL16852379

SCHEMBL16852379

CCOc1ccc(-c2ccc(C)c(F)c2F)cc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.41
KDM1A O60341 2/20 0.41
NAAA Q02083 1/20 0.40
FFAR1 O14842 2/20 0.40
PPARD Q03181 1/20 0.40
PTGS2 P35354 3/20 0.40
FGFR2 P21802 2/20 0.40
FGFR1 P11362 1/20 0.40
PTGS1 P23219 1/20 0.39
PTPRC P08575 1/20 0.38
FFAR4 Q5NUL3 2/20 0.38
PRKCZ Q05513 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
CCNT1 O60563 1/20 0.37
CDK9 P50750 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16855917 0.91 FGFR2 (0.46) FAAHKDM1ANAAAPTGS2FGFR2
SCHEMBL16852383 0.88 FFAR1 (0.42) FFAR1PPARDFFAR4CCNT1CDK9
SCHEMBL13653996 0.87 FGFR2 (0.40) PPARDFGFR2FGFR1PTPRCFFAR4
SCHEMBL16852369 0.87 CCNT1 (0.39) FFAR1PPARDFFAR4CCNT1CDK9
SCHEMBL16856038 0.86 PTGS2 (0.47) KDM1ANAAAPTGS2PTGS1PRKCZ
SCHEMBL16852381 0.86 THRA (0.42) FFAR1PPARDL3MBTL1CCNT1CDK9
SCHEMBL15381834 0.86 FGFR2 (0.39) FGFR2FGFR1PTPRCFFAR4L3MBTL1
SCHEMBL20102498 0.85 KDM1A (0.37) FAAHKDM1ANAAAFFAR1PPARD
SCHEMBL16852375 0.85 THRA (0.44) PPARD
SCHEMBL16852388 0.84 FFAR4 (0.35) FAAHFFAR1PPARDFFAR4PRKCZ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9951274-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2018-04-24 US disclosed
US-20150175884-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2015-06-25 US disclosed
US-20150175884-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2015-06-25 US disclosed