Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15243043 | 0.90 | HDAC6 (0.48) | HDAC6KDM4EALDH1A1OPRL1NR1H2 | |
| SCHEMBL16856764 | 0.81 | KMT2A (0.46) | HDAC6HDAC1HDAC7POLB | |
| SCHEMBL16856726 | 0.81 | LMNA (0.41) | KDM4EALDH1A1NR1H2NR1H3POLB | |
| SCHEMBL17015175 | 0.78 | SMN1; SMN2 (0.41) | HDAC6ALDH1A1HDAC1HDAC7SMN1; SMN2 | |
| SCHEMBL16856698 | 0.78 | CYP19A1 (0.48) | HDAC6ALDH1A1NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL16856696 | 0.72 | GRM2 (0.47) | ALDH1A1CHRM5SMN1; SMN2POLB | |
| SCHEMBL15243031 | 0.71 | KMT2A (0.45) | KDM4EALDH1A1SMN1; SMN2POLBGAA | |
| SCHEMBL16856766 | 0.71 | SIGMAR1 (0.46) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL15242943 | 0.70 | KMT2A (0.47) | HDAC6ALDH1A1HDAC1POLB | |
| SCHEMBL15243035 | 0.69 | CYP11B1 (0.46) | KDM4EALDH1A1NR1H2NR1H3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2889292-B1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA CHEMICALS CORP (CN) | 2020-03-25 | — | — | EP | disclosed |
| US-9586912-B2 | 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method | ABA CHEMICALS CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-9586912-B2 | 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method | ABA CHEMICALS CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | ABA CHEMICALS CORPORATION (CN) | 2015-08-20 | — | — | US | disclosed |
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | ABA CHEMICALS CORPORATION (CN) | 2015-08-20 | — | — | US | disclosed |
| EP-2889292-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA Chemicals Corporation (CN) | 2015-07-01 | — | — | EP | disclosed |
| EP-2889292-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA Chemicals Corporation (CN) | 2015-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | CYP1A2, CYP1B1, CYP3A5 | HDAC6 311/4885KDM4E 4270/4885ALDH1A1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.