Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186183 | 0.83 | ALDH1A1 (0.35) | HCAR2TDP1PKMCYP2C9SMN1; SMN2 | |
| SCHEMBL17627086 | 0.73 | ALDH1A1 (0.35) | TDP1MEN1KMT2AHSD17B10SMN1; SMN2 | |
| SCHEMBL18838974 | 0.73 | MCL1 (0.31) | HCAR2ALDH1A1NPC1HPGDTSHR | |
| SCHEMBL16856709 | 0.72 | NPC1 (0.43) | HCAR2TDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL1930032 | 0.70 | NPSR1 (0.48) | KMT2ACYP2C9CYP2C19HSD17B10SMN1; SMN2 | |
| SCHEMBL3781467 | 0.68 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL936108 | 0.68 | GLA (0.37) | PKMMEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL8308094 | 0.67 | POLB (0.59) | HCAR2TDP1PKMMEN1KMT2A | |
| SCHEMBL4767678 | 0.66 | KDM4E (0.49) | MEN1KMT2AHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL982875 | 0.65 | LMNA (0.53) | MEN1KMT2AHSD17B10SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2889292-B1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA CHEMICALS CORP (CN) | 2020-03-25 | — | — | EP | disclosed |
| US-9586912-B2 | 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method | ABA CHEMICALS CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-9586912-B2 | 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method | ABA CHEMICALS CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-9586912-B2 | 2-substituted-2H-1, 2, 3-triazole derivative and its preparation method | ABA CHEMICALS CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | ABA CHEMICALS CORPORATION (CN) | 2015-08-20 | — | — | US | disclosed |
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | ABA CHEMICALS CORPORATION (CN) | 2015-08-20 | — | — | US | disclosed |
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | ABA CHEMICALS CORPORATION (CN) | 2015-08-20 | — | — | US | disclosed |
| EP-2889292-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA Chemicals Corporation (CN) | 2015-07-01 | — | — | EP | disclosed |
| EP-2889292-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND PREPARATION METHOD THEREOF | ABA Chemicals Corporation (CN) | 2015-07-01 | — | — | EP | disclosed |
| CN-102786485-B | 2-substituted-2H-1,2,3-triazole derivative and preparation method thereof | ABA CHEMICALS CORP | 2014-11-26 | — | — | CN | disclosed |
| CN-102786485-A | 2-substituted-2H-1,2,3-triazole derivative and preparation method thereof | SUZHOU ABA CHEMICALS CORP | 2012-11-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232431-A1 | 2-SUBSTITUTED-2H-1, 2, 3-TRIAZOLE DERIVATIVE AND ITS PREPARATION METHOD | CYP1A2, CYP1B1, CYP3A5 | HCAR2 375/4885TDP1 1800/4885PKM 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.