Benzene

Benzene

SCHEMBL16859313

CC(C)(C)c1c(O)ccc(O)c1C(C)(C)C.O=P(O)(O)O.O=P(O)(O)O.c1ccccc1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
GAA P10253 3/20 0.39
ALDH1A1 P00352 5/20 0.38
TSHR P16473 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
ALOX15 P16050 2/20 0.37
HSD17B10 Q99714 2/20 0.37
HPGD P15428 1/20 0.37
CA2 P00918 2/20 0.36
CA4 P22748 1/20 0.36
CA5A P35218 1/20 0.36
PTPN1 P18031 1/20 0.35
NR1I2 O75469 1/20 0.35
LMNA P02545 1/20 0.35
CYP2C9 P11712 1/20 0.35
MIF P14174 1/20 0.35
TYR P14679 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL27960768 0.95 ALDH1A1 (0.39) MEN1KMT2AGAAALDH1A1TSHR
Phosphoric Acid SCHEMBL8630742 0.85 ALDH1A1 (0.41) MEN1KMT2AGAAALDH1A1TSHR
Phenyl Dihydrogen Phosphate SCHEMBL28106241 0.84 SRC (0.61) ALDH1A1TDP1HSD17B10HPGDCA2
Phosphoric Acid SCHEMBL11111477 0.83 PTPN5 (0.37) MEN1KMT2AGAAALDH1A1TSHR
SCHEMBL30027143 0.83 ALDH1A1 (0.48) MEN1KMT2AGAAALDH1A1TSHR
SCHEMBL70068 0.83 ALDH1A1 (0.48) MEN1KMT2AGAAALDH1A1TSHR
SCHEMBL27963029 0.83 ALDH1A1 (0.48) MEN1KMT2AGAAALDH1A1TSHR
Catechol SCHEMBL28181592 0.78 ALDH1A1 (0.54) MEN1KMT2AGAAALDH1A1TSHR
SCHEMBL14718016 0.77 SRC (0.47) ALDH1A1TDP1CYP2C9
SCHEMBL28887190 0.77 PGK1 (0.40) MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106604949-A Alkoxy polycarbonates, bisphenol monomers, and methods of making and using the same 沙特基础工业全球技术公司 2017-04-26 CN claimed
EP-3137444-A2 ALKOXY POLYCARBONATES, BISPHENOL MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC Global Technologies B.V. (NL) 2017-03-08 EP claimed
WO-2015168225-A2 ALKOXY POLYCARBONATES, BISPHENOL MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-05 WO claimed
US-9994673-B2 Bisphenol polyether oligomers, methods of manufacture, and polycarbonates made therefrom SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2018-06-12 US disclosed
CN-106604949-A Alkoxy polycarbonates, bisphenol monomers, and methods of making and using the same 沙特基础工业全球技术公司 2017-04-26 CN disclosed
EP-3137444-A2 ALKOXY POLYCARBONATES, BISPHENOL MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC Global Technologies B.V. (NL) 2017-03-08 EP disclosed
CN-103732652-B Polysulfone compositions and its manufacture method and its application 沙特基础全球技术有限公司 2016-10-05 CN disclosed
US-20160009859-A1 BISPHENOL POLYETHER OLIGOMERS, METHODS OF MANUFACTURE, AND POLYCARBONATES MADE THEREFROM SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2016-01-14 US disclosed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO disclosed
WO-2015168225-A2 ALKOXY POLYCARBONATES, BISPHENOL MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-05 WO disclosed
US-20150183929-A1 BISPHENOL POLYETHER OLIGOMERS, METHODS OF MANUFACTURE, AND POLYCARBONATES MADE THEREFROM SABIC INNOVATIVE PLASTICS IP B.V (NL) 2015-07-02 US disclosed