Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922767 | 0.89 | ALDH1A1 (0.59) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL873996 | 0.89 | ALDH1A1 (0.63) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL4317881 | 0.89 | ALDH1A1 (0.63) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL873995 | 0.89 | ALDH1A1 (0.63) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL5289694 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL27722063 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL29557745 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL529429 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL22716123 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL27662139 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-9549555-B2 | Macrocyclic picolinamide compounds with fungicidal activity | DOW AGROSCIENCES LLC (US) | 2017-01-24 | — | — | US | disclosed |
| US-9247741-B2 | Use of macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150183759-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC | 2015-07-02 | — | — | US | disclosed |
| US-20150181867-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, CYP4F2 | ALDH1A1 1338/4885TDP1 3279/4885KMT2A 3243/4885 |
| US-20150183759-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | CYP51A1, PFAS, AADAC | ALDH1A1 1424/4885TDP1 2665/4885KMT2A 2871/4885 |
| US-20150181867-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, CYP4F12, CYP1A2 | ALDH1A1 1294/4885TDP1 3465/4885KMT2A 3287/4885 |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | AADAC, CYP51A1, PFAS | ALDH1A1 1415/4885TDP1 2477/4885KMT2A 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.