SCHEMBL16865388

SCHEMBL16865388

O=C1N(c2ccccc2)C(=O)C(Cl)(c2ccccc2)C(=O)N1c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ELANE P08246 5/20 0.47
SMN1; SMN2 Q16637 2/20 0.44
ALDH1A1 P00352 2/20 0.44
LMNA P02545 1/20 0.44
MGLL Q99685 1/20 0.42
GAA P10253 1/20 0.41
GRK5 P34947 1/20 0.38
TYRO3 Q06418 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
PGR P06401 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ITGA4 P13612 1/20 0.37
ITGB7 P26010 1/20 0.37
CNR1 P21554 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16865387 0.80 LMNA (0.41) ELANESMN1; SMN2ALDH1A1LMNAMGLL
SCHEMBL16865393 0.77 ELANE (0.47) ELANEALDH1A1MGLLGAAGRK5
SCHEMBL17716274 0.77 ELANE (0.52) ELANESMN1; SMN2ALDH1A1MGLLGAA
SCHEMBL11654508 0.74 PGR (0.58) ELANEALDH1A1MGLLGAAPGR
SCHEMBL11182628 0.73 MGLL (0.62) ELANEALDH1A1MGLLGAAGRK5
SCHEMBL11287553 0.73 ELANE (0.47) ELANEALDH1A1MGLLGAAGRK5
SCHEMBL16867612 0.73 ELANE (0.43) ELANESMN1; SMN2ALDH1A1LMNAMGLL
SCHEMBL19923463 0.72 ELANE (0.46) ELANESMN1; SMN2ALDH1A1LMNAMGLL
SCHEMBL17716273 0.71 ELANE (0.89) ELANEPGR
SCHEMBL2851080 0.69 MGLL (0.56) ALDH1A1MGLLGAAGRK5TYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND FUJIFILM CORPORATION (JP) 2015-07-02 US disclosed
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND FUJIFILM CORPORATION (JP) 2015-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND C1R, C1S, C3AR1 ELANE 2715/4885SMN1; SMN2 4738/4885ALDH1A1 2148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.