Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 18/20 | 0.66 |
| ▸ | MEN1 | O00255 | 16/20 | 0.66 |
| ▸ | NPC1 | O15118 | 13/20 | 0.66 |
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 11/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282406 | 0.83 | KMT2A (0.62) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12280979 | 0.82 | KMT2A (0.74) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL15613229 | 0.80 | KMT2A (0.56) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12281283 | 0.77 | KMT2A (0.76) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12281829 | 0.75 | KMT2A (0.72) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12280667 | 0.74 | KMT2A (0.66) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL14681431 | 0.72 | KMT2A (1.00) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL27952547 | 0.71 | KMT2A (0.58) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12281794 | 0.70 | KMT2A (0.73) | KMT2AMEN1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL12281111 | 0.69 | KMT2A (0.60) | KMT2AMEN1NPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348295-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA INC (US) | 2017-12-07 | — | — | US | disclosed |
| US-9775835-B2 | Small molecule inhibitors of viral protein interactions with human t-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20150190384-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348295-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | NSUN3, TARBP1, TRDMT1 | KMT2A 2508/4885MEN1 3917/4885NPC1 2010/4885 |
| US-20150190384-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | NSUN3, TARBP1, TRDMT1 | KMT2A 2752/4885MEN1 3866/4885NPC1 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.