Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.73 |
| ▸ | MEN1 | O00255 | 10/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 2/20 | 0.64 |
| ▸ | APP | P05067 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12280667 | 0.89 | KMT2A (0.66) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL3859264 | 0.88 | KMT2A (0.70) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL12280972 | 0.85 | MEN1 (1.00) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL12280671 | 0.80 | KMT2A (0.64) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL14259671 | 0.78 | PIM1 (1.00) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL31654069 | 0.78 | PIM1 (1.00) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL15078624 | 0.77 | KMT2A (0.65) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL18270515 | 0.77 | NFKB1 (0.71) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL10036065 | 0.77 | GLA (0.78) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL11062170 | 0.77 | GLA (0.78) | KMT2AMEN1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | HANSEN MARC (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | HANSEN MARC (US) | 2013-08-29 | — | — | US | disclosed |
| US-8481553-B2 | Antimetastatic compounds | BRIGHAM YOUNG UNIVERSITY (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481553-B2 | Antimetastatic compounds | BRIGHAM YOUNG UNIVERSITY (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011127192-A2 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | KMT2A 3928/4885MEN1 391/4885NPC1 1073/4885 |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | KMT2A 3928/4885MEN1 391/4885NPC1 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.