Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CCNC | P24863 | 6/20 | 0.47 |
| ▸ | CDK8 | P49336 | 6/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MYLK | Q15746 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CILK1 | Q9UPZ9 | 1/20 | 0.47 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773031 | 0.85 | PRKCZ (0.65) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL28212097 | 0.83 | PRKCZ (0.58) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL12386960 | 0.81 | PRKCZ (0.69) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL12074301 | 0.80 | PRKCZ (0.73) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL6243938 | 0.80 | PRKCZ (0.72) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL29501875 | 0.80 | PRKCZ (0.72) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL23555363 | 0.79 | PRKCZ (0.67) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL10600163 | 0.79 | CHRNB4 (0.50) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10806364 | 0.78 | PRKCZ (0.69) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL12074902 | 0.77 | PRKCZ (0.69) | PRKCZCYP11B1CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088757-A1 | NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-12 | — | — | US | disclosed |
| US-8088759-B2 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-01-03 | — | — | US | disclosed |
| US-20070111994-A1 | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111994-A1 | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties | BAD, GABRA5, GABRB1 | PRKCZ 1323/4885CYP11B1 73/4885CYP11B2 71/4885 |
| US-20120088757-A1 | NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES | BAD, GABRA5, GABRB1 | PRKCZ 1323/4885CYP11B1 73/4885CYP11B2 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.