Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.53 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | GRB2 | P62993 | 1/20 | 0.41 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237734 | 0.99 | PTPN1 (0.51) | PTPN1PTPN2TLR2GRB2PTPN9 | |
| SCHEMBL1687864 | 0.89 | PTPN1 (0.46) | PTPN1PTPN2TLR2GRB2 | |
| SCHEMBL19423650 | 0.84 | ROCK2 (0.51) | PTPN1PTPN2TLR2GRB2 | |
| SCHEMBL10236970 | 0.83 | HTRA2 (0.49) | PTPN1PTPN2 | |
| SCHEMBL10237427 | 0.82 | HTRA2 (0.49) | PTPN1PTPN2 | |
| SCHEMBL1687880 | 0.81 | PTPN1 (0.78) | PTPN1PTPN2PTPN9 | |
| SCHEMBL1687879 | 0.79 | PTPN1 (0.75) | PTPN1PTPN2PTPN9 | |
| SCHEMBL7881120 | 0.77 | PTPN1 (0.62) | PTPN1PTPN2PTPN9 | |
| SCHEMBL7883486 | 0.77 | PTPN1 (0.62) | PTPN1PTPN2PTPN9 | |
| SCHEMBL29666861 | 0.77 | PTPN1 (0.51) | PTPN1TLR2GRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176922-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | Indiana University Research and Technology Corpora tion (US) | 2016-06-23 | — | — | US | disclosed |
| US-9217012-B2 | Inhibitors of protein tyrosine phosphatases | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2015-12-22 | — | — | US | disclosed |
| US-20120088720-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176922-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | PTPRCAP, PTPRF, PTPRS | PTPN1 20/4885PTPN2 26/4885TLR2 4768/4885 |
| US-20120088720-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | PTPRCAP, PTPRF, PTPRS | PTPN1 20/4885PTPN2 26/4885TLR2 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.