SCHEMBL1688815

SCHEMBL1688815

CC(C)(C)OC(=O)CNc1ccc(NCC(=O)OC(C)(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.47
PTPRC P08575 2/20 0.42
MAPT P10636 5/20 0.42
ALDH1A1 P00352 2/20 0.40
RAB9A P51151 2/20 0.40
NPC1 O15118 1/20 0.40
HPGD P15428 1/20 0.40
AGTR1 P30556 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
FPR3 P25089 1/20 0.39
FPR2 P25090 1/20 0.39
EGFR P00533 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP17A1 P05093 1/20 0.38
PTPN2 P17706 1/20 0.38
PTPN1 P18031 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1039226 0.93 MAPT (0.47) POLBMAPTALDH1A1AGTR1TDP1
SCHEMBL18740367 0.91 CTNNB1 (0.46) POLBMAPTALDH1A1RAB9ANPC1
SCHEMBL8299387 0.91 FPR2 (0.47) POLBMAPTALDH1A1RAB9ANPC1
SCHEMBL5807704 0.91 POLB (0.42) POLBPTPRCMAPTALDH1A1RAB9A
SCHEMBL9135786 0.91 MAPT (0.52) POLBMAPTALDH1A1RAB9ANPC1
SCHEMBL303932 0.91 PKM (0.46) POLBPTPRCMAPTALDH1A1RAB9A
SCHEMBL9135725 0.90 MAPT (0.53) POLBMAPTALDH1A1RAB9ANPC1
SCHEMBL846596 0.90 MAPT (0.44) POLBPTPRCMAPTALDH1A1RAB9A
SCHEMBL16355781 0.90 MAPT (0.43) POLBMAPTALDH1A1SMN1; SMN2TDP1
Hydrochloric Acid SCHEMBL1169286 0.89 PKM (0.45) POLBPTPRCMAPTALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8901353-B2 Polyimide precursor, polyimide, and liquid crystal aligning agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-12-02 US disclosed
US-8901353-B2 Polyimide precursor, polyimide, and liquid crystal aligning agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-12-02 US disclosed
US-20120088888-A1 POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-04-12 US disclosed
US-20120088888-A1 POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120088888-A1 POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT PUF60, F13A1, F12 POLB 1894/4885PTPRC 3945/4885MAPT 731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.