Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19132763 | 0.84 | RORC (0.36) | RORCHTTGAAHDAC9KMT2A | |
| SCHEMBL19132768 | 0.80 | HTT (0.60) | HTTGAAKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL19132769 | 0.78 | HTT (0.43) | HTTGAAHDAC9MAPK1KMT2A | |
| SCHEMBL19132756 | 0.77 | PDK1 (0.34) | RORCPDK1MAPK1HTR2C | |
| SCHEMBL18217031 | 0.75 | RORC (0.33) | RORCHDAC9KMT2A | |
| SCHEMBL18896278 | 0.73 | HTT (0.59) | HTTGAAKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL17682605 | 0.73 | HTT (0.54) | HTTGAAKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL12507439 | 0.69 | SMN1; SMN2 (0.31) | HTTSMN1; SMN2 | |
| SCHEMBL12489633 | 0.68 | HTR2C (0.48) | HTTGAAKMT2AHTR2CSMN1; SMN2 | |
| SCHEMBL12691665 | 0.68 | CYP2C19 (0.41) | HTTGAAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103507-A1 | CYCLOHEXYL SULFONE RORϒ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |