Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897645 | 0.80 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL29889238 | 0.78 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL16886893 | 0.77 | CRBN (0.55) | CRBNDDB1HTR2AHTR2CHTR2B | |
| SCHEMBL16886328 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL7883858 | 0.77 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL20215842 | 0.76 | OPRM1 (0.39) | CRBNOPRM1 | |
| SCHEMBL8418400 | 0.76 | SSTR5 (0.45) | CRBNDDB1HTR2AHTR2CHTR2B | |
| SCHEMBL16887554 | 0.75 | CRBN (0.61) | CRBNDDB1 | |
| SCHEMBL1632532 | 0.74 | CRBN (0.51) | CRBNDDB1 | |
| SCHEMBL4141843 | 0.73 | HTR2A (0.46) | CRBNDDB1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771320-B2 | Carbocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| WO-2015103508-A1 | CARBOCYCLIC SULFONE RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |