Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16886319 | 0.91 | CRBN (0.57) | CRBNDDB1PDE7B | |
| SCHEMBL16891680 | 0.81 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL2897645 | 0.80 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL29889238 | 0.78 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL16891860 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL16886893 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL7883858 | 0.77 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL18347987 | 0.76 | CHRNB2 (0.38) | CRBNDDB1PDE7B | |
| SCHEMBL18212358 | 0.76 | HRH3 (0.36) | CRBNPDE7B | |
| SCHEMBL7883805 | 0.76 | CRBN (0.45) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458171-B2 | Pyrrolidinyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150191483-A1 | PYRROLIDINYL SULFONE RORGAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191483-A1 | PYRROLIDINYL SULFONE RORGAMMA MODULATORS | RORC, RORB, RORA | CRBN 1895/4885DDB1 4266/4885PDE7B 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.