SCHEMBL16892152

SCHEMBL16892152

Cc1ccc(Oc2cc(N)cc(F)c2)c(F)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 5/20 0.38
SLC6A4 P31645 5/20 0.38
SLC6A3 Q01959 4/20 0.38
ALDH1A1 P00352 5/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP3A4 P08684 1/20 0.37
EPAS1 Q99814 3/20 0.35
HTR1A P08908 1/20 0.35
TEAD4 Q15561 1/20 0.35
GAA P10253 1/20 0.35
HSPB1 P04792 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
POLB P06746 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14662668 0.88 EPAS1 (0.42) SLC6A2SLC6A4SLC6A3EPAS1HTR1A
SCHEMBL27115328 0.85 EPAS1 (0.38) SLC6A2SLC6A4SLC6A3ALDH1A1SMN1; SMN2
SCHEMBL27115327 0.83 ALDH1A1 (0.44) SLC6A2SLC6A4ALDH1A1SMN1; SMN2CYP3A4
SCHEMBL16892153 0.80 TEAD4 (0.59) ALDH1A1SMN1; SMN2CYP3A4TEAD4GAA
SCHEMBL26186321 0.78 SLC6A4 (0.39) SLC6A2SLC6A4SLC6A3ALDH1A1CYP3A4
SCHEMBL25968200 0.78 ALDH1A1 (0.42) SLC6A2SLC6A4SLC6A3ALDH1A1SMN1; SMN2
SCHEMBL328380 0.78 SLC6A4 (0.50) SLC6A2SLC6A4SLC6A3HSPB1
SCHEMBL22199022 0.77 HSPB1 (0.45) SLC6A2SLC6A4SLC6A3ALDH1A1HTR1A
SCHEMBL10269152 0.77 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3ALDH1A1HTR1A
SCHEMBL26493853 0.76 ACHE (0.46) SLC6A2SLC6A4SLC6A3ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150191473-A1 PROTEIN KINASE INHIBITORS PHARMASCIENCE, INC. (CA) 2015-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150191473-A1 PROTEIN KINASE INHIBITORS TEC, SRC, LCK SLC6A2 4121/4885SLC6A4 4405/4885SLC6A3 4334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.