Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 7/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896911 | 0.86 | DRD4 (0.40) | MEN1KMT2ADRD4HDAC1HDAC6 | |
| SCHEMBL20373572 | 0.85 | P2RX7 (0.40) | MEN1KMT2ADRD4HDAC1HDAC6 | |
| SCHEMBL16896736 | 0.81 | DRD4 (0.42) | HTTMEN1POLBKMT2ADRD4 | |
| SCHEMBL18326385 | 0.79 | EZH2 (0.43) | — | |
| SCHEMBL16896933 | 0.78 | HTR2A (0.38) | HTTHTR2AMEN1POLBKMT2A | |
| SCHEMBL16905841 | 0.78 | L3MBTL1 (0.53) | HTTMEN1KMT2ADRD4 | |
| SCHEMBL30659636 | 0.78 | GRM5 (0.40) | HTTHTR2AMEN1POLBKMT2A | |
| SCHEMBL31017016 | 0.76 | RXFP1 (0.46) | HTTHTR2APOLBKMT2A | |
| SCHEMBL30659674 | 0.76 | HTR2A (0.49) | HTTHTR2ATSHR | |
| SCHEMBL20373571 | 0.76 | KDM4E (0.33) | MEN1POLBKMT2ADRD4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104653-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-16 | — | — | WO | disclosed |