Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896788 | 0.86 | HTT (0.43) | DRD4DRD2TSHRMEN1KMT2A | |
| SCHEMBL20373572 | 0.85 | P2RX7 (0.40) | DRD4DRD2TSHRMEN1KMT2A | |
| SCHEMBL16896736 | 0.81 | DRD4 (0.42) | DRD4MEN1KMT2A | |
| SCHEMBL18401134 | 0.77 | TSHR (0.44) | DRD4DRD2TSHRKMT2AHDAC1 | |
| SCHEMBL18326385 | 0.77 | EZH2 (0.43) | EZH2 | |
| SCHEMBL16896871 | 0.77 | L3MBTL1 (0.52) | DRD4MEN1KMT2A | |
| SCHEMBL20373571 | 0.74 | KDM4E (0.33) | DRD4TSHRMEN1KMT2AHDAC1 | |
| SCHEMBL5519023 | 0.73 | SMN1; SMN2 (0.45) | HDAC1HDAC6 | |
| SCHEMBL14641711 | 0.73 | TSHR (0.38) | DRD4DRD2TSHRHDAC1HDAC6 | |
| SCHEMBL12107796 | 0.73 | HTR2C (0.43) | DRD4DRD2TSHRHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104653-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-16 | — | — | WO | disclosed |