Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29718627 | 0.83 | CES2 (0.46) | CES2CES1APP | |
| SCHEMBL24603708 | 0.80 | CNR2 (0.37) | CES2CES1GBA1KAT6AADRA2A | |
| SCHEMBL16896758 | 0.73 | MMP2 (0.45) | SLC9A1SLC9A2LOX | |
| SCHEMBL14938633 | 0.72 | APP (0.52) | APPPTGS2 | |
| SCHEMBL19717529 | 0.71 | CES2 (0.39) | CES2CES1SLC9A1HTT | |
| SCHEMBL11076456 | 0.69 | CYP1A2 (0.37) | SLC9A1SLC9A2LOX | |
| SCHEMBL2061390 | 0.69 | ADRA2A (0.38) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL2642086 | 0.69 | ALB (0.44) | CES2CES1PTGS2HTTADRA2A | |
| SCHEMBL8491731 | 0.68 | CES2 (0.47) | CES2CES1KAT6APTGS2HTT | |
| SCHEMBL775432 | 0.68 | PTGES2 (0.46) | CES2CES1KAT6APTGS2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091970-A1 | LXR AGONISTS AND USES THEREOF | Rgenix, Inc. (US) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015106164-A1 | LXR AGONISTS AND USES THEREOF | RGENIX, INC. (US) | 2015-07-16 | — | — | WO | disclosed |