Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10810171 | 0.85 | GSK3B (0.58) | SMN1; SMN2HPGDL3MBTL1MAPTTDP1 | |
| SCHEMBL7880687 | 0.83 | BRD4 (0.43) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| Hydrochloric Acid SCHEMBL7876724 | 0.82 | BRD4 (0.43) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| SCHEMBL6796759 | 0.81 | MAPT (0.56) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| SCHEMBL6389733 | 0.80 | GSK3B (0.43) | RAB9ASMN1; SMN2NPC1L3MBTL1MAPT | |
| SCHEMBL19958511 | 0.79 | PIN1 (0.72) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| SCHEMBL12100780 | 0.78 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| SCHEMBL12786875 | 0.77 | FBP1 (0.59) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 | |
| SCHEMBL29531896 | 0.76 | FGFR4 (0.48) | HPGDL3MBTL1TDP1ALDH1A1HSF1 | |
| SCHEMBL15179553 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2NPC1HPGDSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079897-B2 | Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors | NOVARTIS AG (CH) | 2015-07-14 | — | — | US | disclosed |