Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19131714 | 0.79 | ENPP3 (0.54) | HSD17B1HSD17B2DHODHMAPTENPP3 | |
| SCHEMBL1505256 | 0.79 | ALDH1A1 (0.51) | HSD17B1HSD17B2DHODHMAPTLMNA | |
| SCHEMBL7040199 | 0.74 | IRAK4 (0.44) | HSD17B1HSD17B2MAPTENPP3ENPP1 | |
| Bromide SCHEMBL6830026 | 0.73 | IRAK4 (0.43) | HSD17B1HSD17B2MAPTENPP3ENPP1 | |
| Bromide SCHEMBL6833472 | 0.72 | CHKA (0.49) | HSD17B1HSD17B2DHODHENPP3ENPP1 | |
| SCHEMBL17920867 | 0.68 | ENPP3 (0.51) | HSD17B1HSD17B2ENPP3ENPP1ALDH1A1 | |
| SCHEMBL7042116 | 0.67 | LTA4H (0.48) | DHODHMAPTPOLBLMNARXFP1 | |
| SCHEMBL19732440 | 0.66 | ENPP3 (0.46) | HSD17B1HSD17B2ENPP3ENPP1KDM4E | |
| Bromide SCHEMBL6830040 | 0.66 | LTA4H (0.47) | DHODHMAPTPOLBLMNARXFP1 | |
| SCHEMBL7221666 | 0.65 | ALDH1A1 (0.58) | HSD17B1HSD17B2KDM4EALDH1A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311455-B1 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS INC (US) | 2015-07-15 | — | — | EP | disclosed |