⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186159 | 0.80 | KDM4E (0.70) | — | |
| SCHEMBL7618500 | 0.80 | KDM4E (0.70) | — | |
| Pyrazinoic Acid SCHEMBL29651929 | 0.78 | — | — | |
| Pyrazinoic Acid SCHEMBL23757 | 0.78 | — | — | |
| SCHEMBL2536804 | 0.78 | — | — | |
| SCHEMBL24027361 | 0.76 | SIRT6 (0.46) | — | |
| SCHEMBL18133270 | 0.76 | — | — | |
| Pyrazinoic Acid SCHEMBL623119 | 0.76 | KDM4E (0.95) | — | |
| Pyrazinamide SCHEMBL24102 | 0.76 | — | — | |
| Pyrazinoic Acid SCHEMBL9478226 | 0.76 | KDM4E (0.95) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220023281-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2022-01-27 | — | — | US | disclosed |
| US-10596175-B2 | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2020-03-24 | — | — | US | disclosed |
| US-20190000852-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2019-01-03 | — | — | US | disclosed |
| EP-2918587-B1 | Filamin A binding compounds and their use as anti-inflammatory and analgesic agents | PAIN THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-3098218-A1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | Gilead Sciences, Inc. (US) | 2016-11-30 | — | — | EP | disclosed |
| EP-2488177-B1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | PAIN THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | disclosed |
| EP-2918587-A2 | Filamin a binding anti-inflammatory and analgesic | Pain Therapeutics, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2015106200-A2 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY (US) | 2015-07-16 | — | — | WO | disclosed |