Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12201514 | 0.84 | LMNA (0.69) | MEN1KMT2ATDP1PKMLMNA | |
| SCHEMBL26363871 | 0.84 | LMNA (0.67) | MEN1KMT2ATDP1LMNAHSD11B1 | |
| SCHEMBL17069876 | 0.84 | POLB (0.57) | MEN1KMT2ATDP1PKMLMNA | |
| SCHEMBL4212319 | 0.82 | MEN1 (0.75) | MEN1KMT2ATDP1MCOLN3LMNA | |
| SCHEMBL17069864 | 0.82 | GAA (0.62) | MEN1KMT2ATDP1PKMHSD11B1 | |
| SCHEMBL16197203 | 0.81 | KMT2A (0.60) | MEN1KMT2ADDIT3LMNAMAPT | |
| SCHEMBL16912989 | 0.81 | SMN1; SMN2 (0.62) | DDIT3LMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL29333973 | 0.81 | ALDH1A1 (0.62) | MEN1KMT2ATDP1PKMLMNA | |
| SCHEMBL16912992 | 0.80 | MEN1 (0.61) | MEN1KMT2ATDP1MCOLN3PKM | |
| SCHEMBL14095893 | 0.80 | MEN1 (0.61) | MEN1KMT2ATDP1MCOLN3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2020-09-29 | — | — | US | disclosed |
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2020-09-29 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | MEN1 4149/4885KMT2A 3270/4885TDP1 1506/4885 |
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | IAPP, TFEB, GBA1 | MEN1 4149/4885KMT2A 3270/4885TDP1 1506/4885 |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | MEN1 4149/4885KMT2A 3270/4885TDP1 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.