SCHEMBL16915380

SCHEMBL16915380

Fc1cccc(Oc2ncc(Br)cn2)c1-c1cc(C(F)F)no1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 1/20 0.31
▸ GRIN1 Q05586 1/20 0.31
▸ GRIN2B Q13224 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29780130 1.00 RXRA (0.31) RXRAGRIN1GRIN2B
SCHEMBL20607623 0.90 POLB (0.31) —
SCHEMBL16915402 0.89 L3MBTL1 (0.32) RXRAGRIN1GRIN2B
SCHEMBL29780129 0.89 L3MBTL1 (0.32) RXRAGRIN1GRIN2B
SCHEMBL28964029 0.88 ALOX5AP (0.34) —
SCHEMBL29780132 0.88 L3MBTL1 (0.30) —
SCHEMBL20607621 0.88 L3MBTL1 (0.30) —
SCHEMBL24107554 0.87 RPS6KB1 (0.31) —
SCHEMBL29981495 0.87 RXRA (0.33) RXRAGRIN1GRIN2B
SCHEMBL27233611 0.87 RXRA (0.33) RXRAGRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4069680-B1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORP (US) 2026-03-25 — — EP claimed
US-12516045-B2 Process for synthesis of a 2-thioalkyl pyrimidine FMC CORPORATION (US) 2026-01-06 — — US claimed
EP-3094631-B2 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2024-12-25 — — EP claimed
US-20230068064-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION 2023-03-02 — — US claimed
EP-4069679-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION (US) 2022-10-12 — — EP claimed
EP-4069680-A1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORPORATION (US) 2022-10-12 — — EP claimed
US-11447476-B2 Pyrimidinyloxy benzene derivatives as herbicides FMC CORPORATION (US) 2022-09-20 — — US claimed
CN-114761384-A Process for the synthesis of 2-thioalkyl pyrimidines FMC公司 2022-07-15 — — CN claimed
CN-114746406-A Method for synthesizing 2- (5-isoxazolyl) -phenol FMC公司 2022-07-12 — — CN claimed
WO-2021113284-A1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORPORATION (US) 2021-06-10 — — WO claimed
US-20200270238-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2020-08-27 — — US claimed
CN-111574510-A Pyrimidinyloxybenzene derivatives as herbicides FMC 公司 2020-08-25 — — CN claimed
CN-105916849-B Pyrimidinyloxybenzene derivatives as herbicides FMC公司 2020-07-07 — — CN claimed
US-10654840-B2 Pyrimidinyloxy benzene derivatives as herbicides FMC CORPORATION (US) 2020-05-19 — — US claimed
US-20190084972-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2019-03-21 — — US claimed
EP-3094631-B1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2019-01-09 — — EP claimed
US-10131652-B2 Pyrimidinyloxy benzene derivatives as herbicides FMC CORPORATION 2018-11-20 — — US claimed
EP-3094631-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2016-11-23 — — EP claimed
US-20160333000-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORPORATION 2016-11-17 — — US claimed
WO-2015108779-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2015-07-23 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10131652-B2 Pyrimidinyloxy benzene derivatives as herbicides DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885
US-10654840-B2 Pyrimidinyloxy benzene derivatives as herbicides DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885
US-20200270238-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885
US-20230068064-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE DHFR, RTF2, RRM2 RXRA 3206/4885GRIN1 3973/4885GRIN2B 4095/4885
US-20160333000-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885
US-11447476-B2 Pyrimidinyloxy benzene derivatives as herbicides DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885
US-20190084972-A1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES DDT, NQO2, CBR3 RXRA 965/4885GRIN1 1381/4885GRIN2B 1671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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