Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 6/20 | 0.75 |
| ▸ | RECQL | P46063 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | PKM | P14618 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 5/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.56 |
| ▸ | APEX1 | P27695 | 5/20 | 0.56 |
| ▸ | BLM | P54132 | 5/20 | 0.56 |
| ▸ | BRCA1 | P38398 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | STAT1 | P42224 | 3/20 | 0.56 |
| ▸ | STAT5A | P42229 | 3/20 | 0.56 |
| ▸ | STAT5B | P51692 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12410283 | 1.00 | TIMP3 (0.75) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL12410284 | 0.94 | TIMP3 (0.86) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL1902159 | 0.87 | TIMP3 (1.00) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL12903191 | 0.86 | TIMP3 (0.72) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL12903193 | 0.84 | TIMP3 (0.62) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL12903190 | 0.80 | TIMP3 (0.78) | TIMP3RECQLKMT2AMAPTMEN1 | |
| SCHEMBL21645072 | 0.79 | RECQL (0.86) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL7223972 | 0.78 | FGF1 (0.63) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL7224031 | 0.76 | TIMP3 (0.57) | TIMP3RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL7234616 | 0.73 | FGF1 (0.62) | TIMP3RECQLKMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303985-A1 | FUSION PROTEINS AND METHODS THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-09-28 | — | — | US | disclosed |
| US-20180030152-A1 | FUSION PROTEINS AND METHODS THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-20160108380-A1 | FUSION PROTEINS AND METHODS THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-21 | — | — | US | disclosed |
| US-20150203589-A1 | FUSION PROTEINS AND METHODS THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030152-A1 | FUSION PROTEINS AND METHODS THEREOF | BCR, RPS27A, FUS | TIMP3 2963/4885RECQL 4353/4885KMT2A 1365/4885 |
| US-20160108380-A1 | FUSION PROTEINS AND METHODS THEREOF | BCR, RPS27A, FUS | TIMP3 2963/4885RECQL 4353/4885KMT2A 1365/4885 |
| US-20230303985-A1 | FUSION PROTEINS AND METHODS THEREOF | BCR, RPS27A, FUS | TIMP3 2963/4885RECQL 4353/4885KMT2A 1365/4885 |
| US-20150203589-A1 | FUSION PROTEINS AND METHODS THEREOF | BCR, RPS27A, FUS | TIMP3 2963/4885RECQL 4353/4885KMT2A 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.